The enzyme arginase-II has an important role in cardiac aging, and blocking it could help hearts stay young longer.

This important study demonstrates the significance of incorporating biological constraints in training neural networks to develop models that make accurate predictions under novel conditions. By ...

Fingertip tactile neurons collectively encode the skin's viscoelastic state alongside current touch, potentially enabling the brain to better interpret forces during manipulation.

This valuable study concerns a model for transgenerational epigenetic inheritance, the learned avoidance by C. elegans of the PA14 pathogenic strain of Pseudomonas aeruginosa. A recent study ...

This important study investigates frequency-dependent effects of transcutaneous tibial nerve stimulation (TTNS) on bladder function in healthy humans and, through a computational model, shows that low ...

Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, United States ...

Nervous necrosis virus typically enters host cells via endocytosis, but it can also enter via a process called macropinocytosis.

This useful manuscript addresses a stability issue for long-term chronically implanted array recordings and electrolytic lesioning, which is relevant to both basic science and translational research.

This important study presents a compelling theoretical framework for understanding phase separation of membrane-bound proteins, with a focus on the organization of tight junction components. By ...

This fundamental study combines in vitro reconstitution experiments and molecular dynamics simulations to elucidate how membrane lipids are transported from the outer to the inner membrane of ...

This is a potentially valuable modeling study on sequence generation in the hippocampus in a variety of behavioral contexts. While the scope of the model is ambitious, its presentation is incomplete ...

These fundamental findings offer a novel mechanism by which rubrerythrin tubules encapsulate encapsulin to prevent oxidative stress in Pyrococcus furiosus. However, there are a few reasonable concerns ...